At his Wednesday press conference, Colts interim head coach Bruce Arians delivered a swift kick to the nuts for anyone with Donald Brown on their fantasy roster:

Arians said Brown was hurt on last play he was in game. Says #Colts RB will be out at least 2-3 weeks. Means he had knee scoped.

— Phillip B Wilson (@pwilson24) October 10, 2012

#Colts RB Donald Brown (torn knee cartilage) is OUT for Sunday. Had surgery Tuesday.

— Phillip B Wilson (@pwilson24) October 10, 2012

Arians said Brown was hurt on last play he was in game. Says #Colts RB will be out at least 2-3 weeks. Means he had knee scoped.

— Phillip B Wilson (@pwilson24) October 10, 2012

With Brown now out, this means fans can expect a steady rotation of rookie Vick Ballard and second-year back Delone Carter.

Brown's injury is a shame. I've bashed him for his whole career because he has been maddeningly inconsistent, but this year things seemed to be turning around a bit.

Look for Ballard to start and Carter to come in on goal-line situations. Mewelde Moore could see increased snaps on passing downs.

Arians also told media that Robert Mathis, Pat Angerer, Fili Moala, and Martin Tevaseu are questionable for Sunday's game against New York.