There is no Loch Ness monster, even though that truck commercial starring him is pretty cool. Big Foot does not exist even though his cameo in a Coors Light commercial is humorous:
And the Colts offense does not struggle against the 3-4 defense even though everyone and their mother says they do, despite the facts.
It doesn't matter what kind of defense you run (3-4, 4-3, 4-6, 5-2, whatever). If you've got great players, more often than not your defense will play well. This is why I get very annoyed when people say "The Colts struggle against a 3-4." Actually, no they don't. The Colts offense has carved up defense's like New England's, New York Jets', and Dallas' many, many times. They trick is to have really good players, regardless of scheme.
It's those defenses the Colts offense (and any other offense) will struggle against.
I also find it funny when people describe "struggling" when the Colts don't score 30 points or something. The standard people have for this offense is nuts! So, when I hear how the Colts struggle against 3-4 defenses like San Diego's, it makes me want to find a 2x4 and smack someone's face in. The Colts offense has not "struggled" against San Diego's 3-4. Since Manning was drafted, the Colts are 3-1 against the Bolts. In 2004, Indy got over 30 points in a win in the Dome in OT. In 2005, the Colts had wrapped up homefield and were playing San Diego (who was desperate to make the playoffs, which they didn't). The Colts had the game in hand until their defense allowed Michael Turner to do his best Gayle Sayers impression, taking a stretch run over 80 yards for a TD.
So, this whole 3-4 myth, like Big Foot, Nessy, and the Trickle-Down Economics theory, is just a bunch of bunk. It's no disrespect for SD, who despite allowing Adrian Peterson to run wild last week, have a good defense. But the Colts offense will "struggle" against any great defense, no matter the scheme.
And with that, I leave you with the greatest Coors Light Press Conference commercial of all!