Two trades since my first mock, so I really should update it.
| Pick# | Team | Player | Position | School |
| 1 | Detroit | Matt Stafford |
QB | Georgia |
| 2 | St. Louis | Jason Smith |
OT | Baylor |
| 3 | Kansas City | Aaron Curry | LB | Wake Forest |
| 4 | Seattle | Mark Sanchez |
QB | USC |
| 5 | Cleveland | Micheal Crabtree | WR | Texas Tech |
| 6 | Cincinnati | Eugene Monroe |
OT | Virginia |
| 7 | Oakland | Jeremy Maclin |
WR | Missouri |
| 8 | Jacksonville | Micheal Oher | OT | Mississippi |
| 9 | Green Bay | B.J. Raji |
DT | Boston College |
| 10 | San Fransisco | Everette Brown |
RushLB | Florida St. |
| 11 | Buffalo | Brian Orakpo | DE | Texas |
| 12 | Denver | Tyson Jackson |
DE | LSU |
| 13 | Washington | Andre Smith | OT | Alabama |
| 14 | New Orleans | Chris Wells | HB | Ohio State |
| 15 | Houston | Brian Cushing |
LB | USC |
| 16 | San Diego | Malcolm Jenkins |
CB/FS | Ohio State |
| 17 | NY Jets | Josh Freeman |
QB | Kansas State |
| 18 | Denver | Rey Malualuga | LB | USC |
| 19 | Tampa Bay | Percy Harvin | WR | Florida |
| 20 | Detroit (from Dallas) | Eben Britton |
OT | Arizona |
| 21 | Philadelphia | Knowshon Moreno | RB | Georgia |
| 22 | Minnesota | Vonte Davis |
CB | Illinois |
| 23 | New England | Clay Matthews Jr. |
LB | Southern Cal |
| 24 | Atlanta | Brandon Pettigrew | TE | Oklahoma St. |
| 25 | Miami | Sean Smith |
CB | Utah |
| 26 | Baltimore | Hakeem Nicks | WR | North Carolina |
| 27 | Indianapolis | Peria Jerry | DT | Mississippi |
| 28 | Buffalo (from CAR via PHI) |
William Beatty |
OT | UConn |
| 29 | NY Giants | Darrius Heyward-Bey |
WR | Maryland |
| 30 | Tennessee | Alphonso Smith | CB | Wake Forest |
| 31 | Arizona | "Shady" McCoy | RB | Pittsburgh |
| 32 | Pittsburgh | Alex Mack | C | California |
| Pick# | Team | Player | Position | School |
| 33 | Detroit | James Laurinatis |
LB | Ohio State |
| 34 | New England (from KC) |
Darrius Butler |
CB | Connecticut |
| 35 | St. Louis |
"Ziggy" Hood |
DT | Missouri |
| 36 | Cleveland | Donald Brown |
RB | Connecticut |
| 37 | Seattle | Josh Freeman |
QB |
Kansas State |
| 38 | Cincinnati | Max Unger |
OC | Oregon |
| 39 | Jacksonville | D.J. Moore |
CB | Vanderbilt |
| 40 | Oakland | Phil Loadholt |
OT | Oklahoma |
| 41 | Green Bay | Aaron Maybin |
DE | Penn State |
| 42 | Buffalo | Duke Robinson |
OG |
Oklahoma |
| 43 | San Fransisco |
Clint Sintim |
OLB | Virgina |
| 44 | Miami (from WAS) | Kenny Britt |
WR | Rudgers |
| 45 | NY Giants (from NO) |
Louis Delmas |
FS | Western Mich. |
| 46 | Houston | Micheal Johnson |
DE | Georgia Tech |
| 47 | New England | Patrick Chung |
SS | Oregon |
| 48 | Denver | Larry English |
LB | Northern Illinois |
| 49 | Chicago | Conner Barwin |
DE |
Cincinnati |
| 50 | Cleveland (from TB) |
Mike Mickens |
CB | Cincinnati |
| 51 | Dallas | William Moore |
S | Missouri |
| 52 | NY Jets |
Shonn Greene |
RB |
Iowa |
| 53 | Philadelphia | Chase Coffman | TE | Missouri |
| 54 | Minnesota | Juaquin Inglesias | WR | Oklahoma |
| 55 | Atlanta | Jarrius Byrd | CB | Oregon |
| 56 | Miami | Robert Ayers |
DE | Tennessee |
| 57 | Baltimore | Fili Moala |
DT |
USC |
| 58 | New England |
Jamon Meredith |
OT |
South Carolina |
| 59 | Carolina | Jarron Gilbert |
DT | San Diego St. |
| 60 | NY Giants |
Asher Allen |
CB |
Georgia |
| 61 | Indianapolis | Brian Robiskie |
WR | Ohio State |
| 62 | Tennessee | Paul Kruger | DE | Utah |
| 63 | Arizona | Ron Brace |
DT | Boston College |
| 64 | Pittsburgh | Dorell Scott |
DT | Clemson |