Two players listed as OUT are Bob Sanders and Austin Collie. No surprises there. Joseph Addai is listed as doubtful, which means he's unlikely to play.
Questionable for the game: Gary Brackett, Brody Eldridge, Mike Hart, Javarris James, Clint Session, Justin Tryon, and Reggie Wayne. Of this group, only James and Wayne are expected to play. Though, I wouldn't be surprised if Mike Hart suits up.
This means Pat Angerer will start at MIKE, and we will see much more of Gijon Robinson at tight end. Running back situation will likely be Donald Brown, Javarris James, and maybe Mike Hart in that order.