Probably the biggest early game is the Cowboys visiting the Texans. Dallas is playing for their season in this game. If they fall to 0-3, they're likely done. The percentage of teams who start 0-3 and make the playoffs is in the single digits. They'll be desperate, hungry, and likely playing for Wade Phillips' job. On the flip side, if Houston wins this game, they are indeed for real.
Other key early games include Bills at Patriots, Titans at Giants, and Browns at Ravens. Enjoy.