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Colts vs. Bills one of the most intriguing week one matchups in the NFL

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It's the first weekend of NFL football, and while there are plenty of interesting matchups, one of the most intriguing ones is the game between the Colts vs. Bills.

Jasen Vinlove-USA TODAY Sports

NFL football is back, and there's a full slate of games this weekend that are intriguing matchups.  Of course, the game between the Steelers and the Patriots Thursday night was a headliner.  And then there's the Bears vs. Packers rivalry that will be played on Sunday.  The Broncos and the Ravens, two of the best in the AFC, face off later in the afternoon.  The matchup of the top two rookie quarterbacks, Jameis Winston and the Buccaneers against Marcus Mariota and the Titans, is Sunday afternoon also.  The Sunday night game is the Giants facing the Cowboys, and then there's a doubleheader on Monday night.

It will be an exciting weekend of NFL football, but one of the most intriguing games will be when the Indianapolis Colts face the Buffalo Bills at 1:00 p.m. Sunday afternoon.

In 2014, the Colts were the number three overall offense (in terms of yards per game) and the number one passing offense, while the Bills were the number four overall defense and the number three passing defense.  The Colts led the NFL in touchdown passes; the Bills led the NFL in sacks.  The Colts were the sixth-highest scoring team in 2014; the Bills allowed the fourth-fewest points.

Entering 2015, the expectations are massively high for both units.  The Colts offense is expected to be one of, if not the, best in the entire league, while Andrew Luck is one of the early favorites to win the MVP award.  The Bills defense is expected to be one of the best in the league this year as well, with the hope that it will carry the team to a potential playoff berth.

And that's not it.  This will also be the debut for new Bills head coach Rex Ryan, who did some good things with the Jets especially early on in his tenure.  He has brought a lot of excitement with him to Buffalo - and fans are pumped up to see the Bills take the field on Sunday with a team that has, perhaps, their best shot to make the playoffs since their last postseason appearance in 1999.  Furthermore, it will be the Bills debut for running back LeSean McCoy, who emerged as one of the best running backs in the NFL while with the Eagles.

When you combine all of that, it adds up to one of the more interesting games of the weekend.  Our own Matt Grecco predicted that the Colts will finish the season as the number one passing offense while the Bills will finish the season with the number one passing defense.  It's only the first week, but these two teams could both have successful seasons and Sunday could be an exciting matchup that could provide one of the biggest tests for both teams all season.