The Indianapolis Colts took the long trip west to play the 49ers in Santa Clara on Sunday Night Football. Both teams have managed only two wins to start the season, putting both in an early hole in their respective divisions. It’s no surprise to see San Francisco favored at home — DraftKings sportsbook has the Niners as -4 point favorites — but it’s also reasonable to see this is one of the top upset candidates of the weekend.
The weather forecast includes rain and warnings for gale-force winds that will remain active through the game. These are game conditions that likely favor the team with the advantage in the trenches and on the ground. Arguably, the Colts offensive line and dominant second-year rusher Jonathan Taylor should have the advantage. The Colts defense has also been good against opposing running games and the 49ers have an unsettled backfield situation.