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Opening NFL odds Week 10 - Colts 10.5 point favorites versus Jaguars

NFL: Jacksonville Jaguars at Indianapolis Colts Trevor Ruszkowski-USA TODAY Sports

Every Sunday, our partners at DraftKings take an early look ahead to the following week’s games. If you’re looking to get an early start, visit the Opening Odds on DraftKings Sportsbook.

A recurring theme for the Colts moving forward is that their opponent is inconsequential. Yes, a divisional win is important. Yes, the Colts need to take care of business against the Jacksonville Jaguars. But, until the Titans show signs of a meaningful collapse, the Colts are playing for a Wild Card berth. Under those circumstances, it’s the overall record that will win the day.

The Jaguars stunned the Buffalo Bills today, a team that many thought might be the favorite to represent the AFC in this year’s Super Bowl. They did so with a rookie quarterback and despite very low in-season expectations. They’ve won two of their last three contests. Are they hitting their stride? Is the NFL sleeping on Jacksonville?

Odds/lines subject to change. T&Cs apply. See for details.