According to ESPN’s Field Yates, the Indianapolis Colts will host the Seattle Seahawks during the team’s opener of the 2021 regular season at 1 PM EST on Sunday, September 12th (FOX):
The full slate of Week 1 FOX games:— Field Yates (@FieldYates) May 12, 2021
* Vikings at Bengals, 1 PM ET
* 49ers at Lions, 1 PM ET
* Eagles at Falcons, 1 PM ET
* Seahawks at Colts, 1 PM ET
* Broncos at Giants, 4:25 PM ET
* Packers at Saints, 4:25 PM ET
The reigning NFC West Champions finished 12-4 last season before losing to the Los Angeles Rams 30-20 during the Wild Card round of this past year’s playoffs.
The Colts franchise is 7-5 lifetime against the Seahawks, with their last inter-conference head-to-head matchup being in 2017—where Indianapolis fell on the road 46-18 in early October of that season (without Andrew Luck and with Jacoby Brissett behind center).
The two teams did meet in Seattle during Week 1 of preseason in 2018, in a 19-17 Colts’ win.
Of course, this year’s Colts defense will have a tough assignment against 8x Pro Bowler Russell Wilson—while new starting quarterback Carson Wentz makes his Indianapolis debut on the other side of the football.
The NFL schedule will be officially released Wednesday at 8 PM EST on NFL Network.